4-DMA-7,8-DHF (4-Dimethylamino-7,8-dihydroxyflavone) is a synthetic flavonoid derivative and a potent, orally bioavailable small-molecule agonist of the tropomyosin receptor kinase B (TrkB). It is a structural analog of 7,8-DHF, but with enhanced blood-brain barrier permeability and metabolic stability due to the dimethylamino substitution. By activating TrkB, the primary receptor of brain-derived neurotrophic factor (BDNF), 4-DMA-7,8-DHF mimics BDNF's neurotrophic effects-promoting neuronal survival, synaptic plasticity, and neurogenesis.
