Humanin is a naturally occurring bioactive peptide originally identified as a cytoprotective factor, and has since gained significant attention in cosmetic science for its remarkable anti-aging and skin-protective properties. It functions by binding to specific receptors on skin cells, activating intracellular survival pathways that counteract oxidative damage, reduce inflammation, and prevent premature cellular senescence. Humanin also promotes mitochondrial homeostasis and enhances the skin's natural repair mechanisms, leading to improved barrier function, increased elasticity, and a more youthful complexion. With excellent biocompatibility and low irritancy, Humanin is an ideal active ingredient for high-performance serums, anti-aging creams, and rejuvenating formulations.