Rigin (Palmitoyl Tetrapeptide-7) is a bioactive peptide commonly used in anti-aging and skin-restorative cosmetic formulations. It consists of a chain of four amino acids (tetrapeptide) conjugated with a palmitic acid moiety, which enhances its lipophilicity and allows for better dermal absorption. This peptide is known for its ability to modulate the skin's inflammatory response by downregulating the production of pro-inflammatory cytokines, particularly interleukin-6 (IL-6), which is associated with age-related skin degradation and glycation damage. By reducing chronic low-grade inflammation-often referred to as "inflammaging"-Rigin helps restore skin homeostasis, improve elasticity, and diminish the appearance of fine lines and wrinkles. It is frequently combined with other peptides, such as Matrixyl, to provide synergistic anti-aging benefits, and is considered gentle, non-irritating, and suitable for long-term daily use.
